Regarding “Statins, heme oxygenase-1, iron, and atherosclerosis”
نویسندگان
چکیده
منابع مشابه
Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis
Atherosclerosis is an inflammatory process of the vascular wall characterized by the infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density lipoproteins and induction of oxidative stress play a major role in lipid retention in the vascular wall, uptake by macrophages and generation of foam cells, a hallmark of this disorder. The vasculature has a plet...
متن کاملHeme oxygenase and atherosclerosis.
Overproduction of reactive oxygen species under pathophysiological conditions, including dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of cardiovascular diseases (CVD). The reactive oxygen species released from all types of vascular cells regulate various signaling pathways that mediate not only vascular inflammation in atherogenesis but also antioxidative an...
متن کاملHeme Oxygenase-2 Gene Mutations and Blood Bilirubin Level in Iranian Patients with Premature Atherosclerosis
Heme oxygenase-2 (HO-2) is a critical antioxidative stress enzyme found in endothelial cells and adventitialnerves. This enzyme in conjunction with other HOs (1 and 3) metabolize heme molecule into ferrous iron,carbon monoxide (CO), and biliverdin which is further converted to bilirubin. Both biliverdin and bilirubin arepotent antioxidants, reducing the risk of atherosclerosis...
متن کاملProtective role of heme oxygenase-1 against inflammation in atherosclerosis.
Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting step in the metabolism of free heme into equimolar amounts of ferrous iron, carbon monoxide (CO), and biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. HO-1 has recently been identified as a promising therapeutic target in the treatment of vascular inflammatory disease, including atherosclerosis. ...
متن کاملIron Supplementation Alters Heme and Heme Oxygenase 1 (HO-1) Levels In Pregnant Women in Ghana.
BACKGROUND Iron supplementation is recommended for pregnant women to meet their iron requirement for a healthy pregnancy. The benefits and risks of universal iron supplementation during pregnancy in malaria endemic countries are currently being debated. As part of a broader study that focused on the effect of heme/HO-1 on pregnancy outcomes in malaria in pregnancy, we determined the association...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2010
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2010.04.052